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There is no clinical research supporting the safety or efficacy of such a combination, and it significantly increases the risk of severe gastrointestinal side effects and potentially other serious adverse events

doi: 10.1007/s10456-021-09824-3 260 ShellenbergerTDWangMGujratiMJayakumarAStrieterRMBurdickMDet al

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Heffron and his colleagues also conducted a subgroup analysis, collecting trials that compared GLP-1 agonists with DPP-4 inhibitors (an older class of diabetes medications), both of which raise blood levels of GLP-1